Established in 1972 by Ljubljana Urban Municipality, the Architecture Museum of Ljubljana houses a permanent display of oeuvres by leading Slovene architect Jože Plečnik ().Originally located in the Plečnik House at 4 Karunova, it was relocated to Fužine Castle in 1992. The Architectural Museum also maintains Plečnik House. Since 1972 the Secretariat of the BIO - Biennial of Industrial Design operates under the aegis of the museum. From 1988 to 2004 the museum managed the Jakopič Gallery.

The Museum's activities have expanded since the move to Fužine Castle. The museum now incorporates departments of historical architecture in Slovenia , of contemporary Slovene architecture, and departments of industrial design, visual communications and visual design for electronic media and photography. The museum houses also a specialised Library.

The Museum organises special themed historical exhibitions, eg The Modern Classic Arne Jacobsen : A Centenary Exhibition (2004), 17th Century Architecture in Slovenia (2006) and 18th Century Architecture in Slovenia (2007), as well as regular exhibitions of international architecture.

Lectures and other educational activities take place regularly at the Museum. In the ARK - Institute for Architecture and Culture organised a series of lectures at the Museum under title Architectural Epicentres. These lectures focused on seven epicentres - Brazil and Mexico in the 1950s, Finland in the 1960s, Switzerland and USA in the 1980s, Barcelona in the 1990s, and the Netherlands at the close of the 20th century, while the concluding lecture focused on Slovenia and the (im)possibility of its becoming one of the next architectural epicentres. The lecturers were Keith L Eggener, Hugo Segawa, Harri Kalha, Bart Lootsma, Nott Chaviezel, Mary McLeod, Jose Luis Echeverre, Yasushi Zenno, Rado Riha and Boštjan Vuga.

In 2008 the Architecture Museum of Ljubljana in collaboration with the PEKINPAH Association are preparing a series of lectures in design theory about sustainable alternatives in design with international lecturers.